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However, a proteasome-independent mechanism might also contribute to CIPN

Normally, about 80% of Hcy is bound to plasma proteins such as albumin by disulfide bonds, and the rest of Hcy is mostly bound to thiols in the form of cystine or other forms, while only a small portion is free

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Interesting prospects have also been opened up by the analysis of antimicrobial peptides (AMPs), i.e., agents involved in intestinal innate immune system, which are useful in neutralizing bacteria and interacting with bacterial cell walls or membranes [79]

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